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Table 2 Relationship between HLA-DRB1 allele carrier status and rheumatoid factor status in French patients with early rheumatoid arthritis

From: A new classification of HLA-DRB1 alleles differentiates predisposing and protective alleles for autoantibody production in rheumatoid arthritis

  Carrier status Odds ratio (95% confidence interval) P P for trend
  Yes No    
S1 carrier      
   Rheumatoid factor-positive 31 (55.4) 79 (75.9) 0.39 (0.19–0.83) 0.0118 0.0051*
   Rheumatoid factor-negative 25 (44.6) 25 (24.0)    
S2 carrier      
   Rheumatoid factor-positive 49 (83.1) 61 (60.4) 3.21 (1.39–7.9) 0.0028* 0.0049*
   Rheumatoid factor-negative 10 (16.9) 40 (39.6)    
S3P carrier      
   Rheumatoid factor-positive 57 (74.0) 53 (63.9) 1.61 (0.78–3.38) 0.1766 0.4478
   Rheumatoid factor-negative 20 (26.0) 30 (36.1)    
S3D carrier      
   Rheumatoid factor-positive 19 (51.4) 91 (74.0) 0.37 (0.16–0.86) 0.0145 0.0209
   Rheumatoid factor-negative 18 (48.6) 32 (26.0)    
  1. Data presented as n (%). Status for rheumatoid factor among 160 patients with early rheumatoid arthritis, carrying the different HLA-DRB1 alleles encoding the shared epitope classified into four groups according to the new classification. Odds ratios, 95% alpha-risk confidence interval and P value for exact Fisher test. The dose effect was investigated for alleles positively or negatively associated with immunological markers using tests for trend of the log odds. *Significant after correcting for multiple testing according to the Benjamini–Yekutieli 2001 method at an overall critical P value of 5%.