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Table 2 Association between diplotype configurations at the NAT2 gene and adverse events with co-trimoxazole, analyzed in the cohort study

From: Association of the diplotype configuration at the N-acetyltransferase 2 gene with adverse events with co-trimoxazole in Japanese patients with systemic lupus erythematosus

Diplotype configuration Acetylator phenotype With adverse events (n = 18) Without adverse events (n = 36) Total
   NAT2*4/*4 Fast 6 15 21
   NAT2*4/*5B Fast 0 2 2
   NAT2*4/*5E Fast 0 1 1
   NAT2*4/*6A Fast 5 12 17
   NAT2*4/*7B Fast 2 4 6
Fast acetylators 13 (27.7) 34 (72.3) 47
   NAT2*6A/*6A Slow 1 0 1
   NAT2*6A/*7B Slow 3 1 4
   NAT2*7B/*7B Slow 1 1 2
Slow acetylators 5 (71.4)a 2 (28.6) 7
  1. Values are expressed as number (%) of patients. The frequency of adverse events was compared between fast acetylators (n = 47) and slow acetylators (n = 7). aP = 0.034 versus fast acetylators (by Fisher's exact test); relative risk = 2.58, 95% confidence interval = 1.34–4.99. NAT2, N-acetyltransferase 2.