Association of the diplotype configuration at the N-acetyltransferase 2 gene with adverse events with co-trimoxazole in Japanese patients with systemic lupus erythematosus

Table 2 Association between diplotype configurations at the NAT2 gene and adverse events with co-trimoxazole, analyzed in the cohort study

Diplotype configuration	Acetylator phenotype	With adverse events (n = 18)	Without adverse events (n = 36)	Total
NAT24/4	Fast	6	15	21
NAT24/5B	Fast	0	2	2
NAT24/5E	Fast	0	1	1
NAT24/6A	Fast	5	12	17
NAT24/7B	Fast	2	4	6
Fast acetylators		13 (27.7)	34 (72.3)	47
NAT26A/6A	Slow	1	0	1
NAT26A/7B	Slow	3	1	4
NAT27B/7B	Slow	1	1	2
Slow acetylators		5 (71.4)^a	2 (28.6)	7

Values are expressed as number (%) of patients. The frequency of adverse events was compared between fast acetylators (n = 47) and slow acetylators (n = 7). ^aP = 0.034 versus fast acetylators (by Fisher's exact test); relative risk = 2.58, 95% confidence interval = 1.34–4.99. NAT2, N-acetyltransferase 2.

ISSN: 1478-6362