Skip to main content


Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 4 Association between diplotype configurations at the NAT2 gene and severe adverse events with co-trimoxazole, analyzed in the case-control study

From: Association of the diplotype configuration at the N-acetyltransferase 2 gene with adverse events with co-trimoxazole in Japanese patients with systemic lupus erythematosus

Diplotype configuration With severe adverse events (n = 5) Without severe adverse events (n = 52)
Slow acetylator (without NAT2*4) 3 (60)a 6 (11.5)
Fast acetylator (with NAT2*4) 2 (40) 46 (88.5)
  1. Values are expressed as number (%) of patients. The frequency of slow acetylators was compared between five patients who experienced severe adverse events and 52 patients without severe adverse events. aP = 0.024 by Fisher's exact test; odds ratio = 11.5, 95% confidence interval = 1.59–73.39. NAT2, N-acetyltransferase 2.