Association of the diplotype configuration at the N-acetyltransferase 2 gene with adverse events with co-trimoxazole in Japanese patients with systemic lupus erythematosus

Table 4 Association between diplotype configurations at the NAT2 gene and severe adverse events with co-trimoxazole, analyzed in the case-control study

Diplotype configuration	With severe adverse events (n = 5)	Without severe adverse events (n = 52)
Slow acetylator (without NAT24*)	3 (60)^a	6 (11.5)
Fast acetylator (with NAT24*)	2 (40)	46 (88.5)

Values are expressed as number (%) of patients. The frequency of slow acetylators was compared between five patients who experienced severe adverse events and 52 patients without severe adverse events. ^aP = 0.024 by Fisher's exact test; odds ratio = 11.5, 95% confidence interval = 1.59–73.39. NAT2, N-acetyltransferase 2.

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