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Table 2 BMP signaling in synovitis

From: Bone morphogenetic proteins in destructive and remodeling arthritis

Ex vivo human biopsies Increased expression of BMP2 and BMP6 [9]
  Decreased expression of BMP4 and BMP5 [41]
  Presence of BMP receptor Ia positive cells in RA [38]
Animal model data Influx of BMP receptor Ia positive cells precedes onset of arthritis [39]
  1. BMP, bone morphogenetic protein; RA, rheumatoid arthritis.