Figure 2
From: Arthritis and pain. Current approaches in the treatment of arthritic pain
Causes and consequences of neural plasticity. Although tissue injury or inflammation can trigger nociceptor sensitization in peripheral neurons (1), other somatic, psychological and environmental influences are likely to determine the magnitude of any subsequent change as a result of modulation of activity at spinal (2) or cortical (3) levels. (Adapted from [3].)