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Table 2 Patient characteristics

From: Contribution for new genetic markers of rheumatoid arthritis activity and severity: sequencing of the tumor necrosis factor-alpha gene promoter

  

Disease duration

 

Characteristics

Total

<2 years

2–10 years

>10 years

Percentage of data missing

Number of patients (percentage)

491

70 (14)

174 (36)

236 (48)

-

Females/males, n (percentage)

417/74 (85/15)

50/10

150/24

206/30

-

Age at disease onset in years, mean (SD)

57.4 (13.3)

55.4 (16.8)

54.8 (14.0)

60.0 (11.0)

2%

Years of education, mean (SD)

5.8 (4.3)

6.0 (4.5)

7.0 (4.7)

4.8 (3.7)

7%

Family history of RA, n (percentage)a

67/400 (14/81)

8/62

18/152

41/183

5%

Disease duration in years, mean (SD)

12.7 (10.5)

-

-

-

2%

Number of previous DMARDs, mean (SD)

2.3 (1.6)

1.3 (1.1)

2.1 (1.4)

2.7 (1.8)

2%

Dose of prednisolone in milligrams, mean (SD)

5.9 (3.7)

6.1 (4.1)

5.8 (3.8)

5.8 (3.4)

3%

Biologics, n (percentage)a

150/339 (30/69)

4/65

53/121

150/85

1%

Health Assessment Questionnaire score, mean (SD)

1.18 (0.8)

0.97 (0.7)

1.04 (0.8)

1.36 (0.9)

6%

DAS28, mean (SD)

4.14 (1.5)

4.4 (1.7)

4.1 (1.5)

4.0 (1.5)

3%

Submitted to joint surgery, n (percentage)a

113/366 (23/74)

1/68

21/152

91/143

3%

Work disability, n (percentage)a

282/200 (57/41)

38/32

80/84

161/74

2%

Systemic manifestations, n (percentage)a

124/357 (25/73)

8/62

32/141

81/154

2%

Rheumatoid factor, n (percentage)a

319/124 (65/25)

44/22

106/52

166/48

10%

Sharp/van der Heijde score, mean (SD)

117.2 (77.8)

-

-

-

34%

  1. aValues presented indicate yes/no. DAS28, disease activity score using 28 joint counts; DMARD, disease-modifying anti-rheumatic drug; RA, rheumatoid arthritis; SD, standard deviation.