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Table 2 Summary of the frequency of positive expression of antibodies to various ribosomal P protein components in cerebrospinal fluida

From: Association of cerebrospinal fluid anti-ribosomal P protein antibodies with diffuse psychiatric/neuropsychological syndromes in systemic lupus erythematosus

  Percentage positiveb
  Control Diffuse NP-SLE Focal NP-SLE
Anti-PC22 4.2% (1/24) 23.1% (12/52) 5.3% (1/19)
Anti-whole P 0% (0/24) 78.8% (41/52) 31.6% (6/19)
Anti-PEX.C22 4.2% (1/24) 65.4% (34/52) 26.3% (5/19)
Anti-C22-depleted rP0 5.3% (1/19) 44.7% (21/47) 5.6% (1/18)
  1. aAntibodies to the C-terminal 22-amino acid sequence of ribosomal P protein (anti-PC22), to highly purified ribosomal P proteins (anti-whole P), to the epitopes other than the C-terminal 22-amino acid sequence (anti-PEX.C22), and to recombinant ribosomal P0 protein lacking the C-terminal 22-amino acid sequence (anti-C22-depleted rP0) in cerebrospinal fluid from patients with non-inflammatory neurological diseases (Control), with diffuse neuropsychiatric systemic lupus erythematosus (NP-SLE), or with focal NP-SLE were compared. bCutoff values were set as the mean + 3 standard deviations of the values in control group. Values in parenthesis mean (numbers of patients with positive results/total patient numbers) in each group.