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Table 3 Comparison of PTPN22 1858 genotypes in rheumatoid arthritis patients stratified according to anti-cyclic citrullinated peptide (anti-CCP) antibodies and rheumatoid factor with all controls

From: The PTPN221858C/T polymorphism is associated with anti-cyclic citrullinated peptide antibody-positive early rheumatoid arthritis in northern Sweden

  CT + TT genotype, n (%) CC genotype, n (%) Minor allele frequency Cases versus all controlsa
     χ2 P value Pc value Odds ratio 95% confidence interval
Anti-CCP antibody-positive 113 (35.5) 205 (64.5) 0.196 24.99 0.0000006 0.0000024 2.01 1.51–2.67
Anti-CCP antibody-negative 40 (26.7) 110 (73.3) 0.145 1.97 0.16046 0.64184 1.32 0.88–2.00
Rheumatoid factor-positive 96 (36.4) 168 (63.6) 0.199 24.49 0.0000007 0.0000028 2.08 1.53–2.82
Rheumatoid factor-negative 28 (27.5) 74 (72.5) 0.142 1.87 0.17164 0.68656 1.38 0.85–2.23
  1. Pc, corrected P value. aControls presented in Table 2