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Table 3 Comparison of PTPN22 1858 genotypes in rheumatoid arthritis patients stratified according to anti-cyclic citrullinated peptide (anti-CCP) antibodies and rheumatoid factor with all controls
| CT + TT genotype, n (%) | CC genotype, n (%) | Minor allele frequency | Cases versus all controlsa | |||||
|---|---|---|---|---|---|---|---|---|
| χ2 | P value | Pc value | Odds ratio | 95% confidence interval | ||||
| Anti-CCP antibody-positive | 113 (35.5) | 205 (64.5) | 0.196 | 24.99 | 0.0000006 | 0.0000024 | 2.01 | 1.51–2.67 |
| Anti-CCP antibody-negative | 40 (26.7) | 110 (73.3) | 0.145 | 1.97 | 0.16046 | 0.64184 | 1.32 | 0.88–2.00 |
| Rheumatoid factor-positive | 96 (36.4) | 168 (63.6) | 0.199 | 24.49 | 0.0000007 | 0.0000028 | 2.08 | 1.53–2.82 |
| Rheumatoid factor-negative | 28 (27.5) | 74 (72.5) | 0.142 | 1.87 | 0.17164 | 0.68656 | 1.38 | 0.85–2.23 |
