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Table 6 DRB1-/DQA1-DQB1 haplotype distribution in rheumatic fever and rheumatic heart disease patients compared with control subjects

From: HLA class II DR and DQ genotypes and haplotypes associated with rheumatic fever among a clinically homogeneous patient population of Latvian children

 

Haplotype

Group

*04-*0401*-0301

*04-*0301-*0401-2

*07-*0201-*0302

*15-*0102-*0602-8

All RF (n = 70)

0.01

0.02

0.04/21.94 (0.001)

0.08/0.88 (0.67)

MVR (n = 48)

0.02

0.02/5.07 (0.25)

0.04/2.27 (0.27)

0.06

MVL (n = 40)

ND

0.02

0.05/26.0 (0.001)

0.10/1.1 (0.5)

Sydenham's chorea (n = 16)

0.04/16.6 (0.003)

0.13/78.0 (0.0001)

ND

0.12/1.5 (0.44)

Without RHD (n = 46)

0.04

0.04

0.06/35.1 (0.002)

0.08/1.0 (0.61)

Control subjects (n = 100)

0.004

0.002

0.002

0.09

  1. Values are allele frequency/odds ratio (p value) and are reported only for significant associations (p < 0.05); n = number of haplotypes (for example, 140 alleles from 70 individuals and 200 alleles from 100 individuals). Entries in bold are statistically significant associations for patients versus controls. MVL, multivavular lesion (mitral regurgitation + aortic valve regurgitation); MVR, mitral valve regurgitation; ND, not determined; RF, rheumatic fever; RHD, rheumatic heart disease.
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Arthritis Research & Therapy

ISSN: 1478-6362

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