Table 1 Pharmacokinetics of TRU-015
Group (mg/kg) | Area under the curve from time 0 to infinity (μg/h/ml) | Maximum concentration of drug (μg/ml) | Half-life (hours) | Coefficient of variability (%) |
|---|---|---|---|---|
0.5 | 1,342 | 13.8 | 281 | 59.1 |
1.5 | 7,082 | 58.2 | 282 | 26.5 |
5 | 18,140 | 154 | 295 | 33.4 |
15 | 71,753 | 462 | 409 | 32.8 |