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Table 1 Quantification of histological changes in the hind paws of Celastrus-fed (experimental) versus water-fed (control) Lewis rats

From: Celastrus aculeatusMerr. suppresses the induction and progression of autoimmune arthritis by modulating immune response to heat-shock protein 65

Group (n) Cellular infiltratea Synovial hyperplasiaa Cartilage damagea Bone erosiona
Water-fed     
   Day 12 (10) 2 (1–3) 3 (2–3) 2.5 (0–3) 2.5 (0–3)
   Day 24 (10) 3 (2–3) 3 (3–3) 3 (1–3) 3 (0–3)
Celastrus-fed     
   Day 12 (10) 1 (0–2)* 0 (0–2)* 0 (0–2)* 0 (0–1)*
   Day 24 (9) 1 (0–3)* 1 (0–2)* 1 (0–2)* 1 (0–1)*
  1. The results shown are the median (interquartile range) scores of histological sections of the left or the right hind paw using the grading system described in 'Materials and methods'. aHistological grading of each parameter was done as follows: 0 = absent; 1 = mild; 2 = moderate; 3 = severe. *p < 0.01, comparing the results of the respective Celastrus-fed versus water-fed groups.