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Table 6 Independent associations of autoantibodies with specific sets of clinical features, therapeutic outcomes, and myositis course by stepwise multiple logistic regression in 100 patients with autoimmune myositis

From: Heterogeneity of autoantibodies in 100 patients with autoimmune myositis: insights into clinical features and outcomes

Autoantibodies

Clinical featuresa

OR

95% CI

P

Anti-Jo-1b

Interstitial lung disease

14.5

3.52 to 59.78

<0.001

 

Arthritis

11.6

2.92 to 45.65

<0.001

 

Fever

9.7

2.72 to 34.91

<0.001

 

Puffy hands

9.6

2.82 to 32.92

<0.001

 

Associated CTD

0.14

0.03 to 0.70

0.016

 

Response to prednisone alone

0.04

0.01 to 0.32

0.002

 

Need for second line drug

25.3

4.24 to 150

<0.001

Anti-fibrillarin

Raynaud's phenomenon

10.9

2.83 to 42.60

<0.001

 

Any lung involvement

3.5

1.01 to 12.39

0.050

 

Associated CTD

4.1

1.14 to 14.50

0.031

Anti-U1RNP

Raynaud's phenomenon

9.8

2.28 to 42.59

0.002

 

Arthritis

5.8

1.74 to 19.18

0.004

 

Sclerodactily

6.8

2.03 to 22.49

0.001

 

Associated CTD

6.8

1.76 to 26.55

0.006

 

Associated SSc

6.1

1.83 to 20.26

0.003

 

Monophasic myositis course

8.1

1.39 to 46.7

0.020

SSc autoantibodies

Telangiectasias

19.3

2.05 to 181.51

0.010

 

Sclerodactyly

8.6

1.88 to 39.60

0.005

 

Scleroderma proximal to MCP

5.3

1.07 to 26.78

0.041

 

Associated SSc

5.8

1.29 to 25.78

0.022

Anti-Ro or anti-Ro52

Response to prednisone alone

6.2

1.23 to 31.64

0.027

 

Need for second line drug

0.12

0.03 to 0.54

0.006

  1. Clinical associations were determined at myositis diagnosis, whereas associations with specific myositis courses and therapeutic responses were determined at last follow up. Results were very similar when adjusted for age and sex. See Materials and methods (in the text) for definitions of clinical findings. aDefinitions were previously described by Troyanov and coworkers [14]. bAnti-Jo-1 (or anti-synthetases overall) were also associated with higher serum creatine kinase at myositis diagnosis (OR 5.3; P < 0.0001). CI, confidence interval; CTD, connective tissue disease; DM, dermatomyositis; MCP, metacarpophalangeal joints; OR, odds ratio; SSc, systemic sclerosis.