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Table 2 Comparison of the baseline and the change in hand bone mineral density

From: Hand bone loss as an outcome measure in established rheumatoid arthritis: 2-year observational study comparing cortical and total bone loss

  Disease duration DAS28 at baseline MHAQ at baseline
  ≤3 years >3 years P value* <3.2 3.2–5.1 >5.1 P value <1.50 1.50–1.99 ≥2.0 P value
n 37 178 <0.01 55 103 44 <0.01 102 78 34 <0.01
Age (years) 55.4 (43–62) 58.0 (50–65) 0.10 53.5 (39–61) 55.8 (49–64) 62.2 (57–67) <0.01 53.6 (41–64) 58.9 (52–64) 61.2 (54–67) <0.01
DXA-BMD (g/cm2) 0.39 (0.34–0.43) 0.36 (0.31–0.41) 0.04 0.40 (0.36–0.43) 0.38 (0.32–0.42) 0.33 (0.28–0.38) <0.01 0.38 (0.33–0.43) 0.37 (0.31–0.41) 0.34 (0.30–0.39) 0.13
DXA-BMD change (%) -0.96 (-4.4 to 1.5) 0.24 (-1.4 to 2.1) <0.01 -0.40 (-2.4 to 1.8) 0.26 (-1.3 to 2.2) 0.04 (-3.4 to 2.2) 0.40 0.11 (-2.5 to 2.1) 0.0 (-1.2 to 2.0) -0.12 (-4.1 to 2.2) 0.75
DXR-BMD (g/cm2) 0.57 (0.50–0.61) 0.51 (0.44–0.56) <0.01 0.56 (0.50–0.61) 0.53 (0.45–0.58) 0.46 (0.38–0.52) <0.01 0.54 (0.49–0.59) 0.49 (0.44–0.57) 0.50 (0.40–0.53) <0.01
DXR-BMD change (%) -0.46 (-3.6 to 0.2) -0.93 (-2.8 to 0.3) 0.76 -0.29 (-1.6 to 0.7) -1.13 (-3.2 to 0.1) -1.03 (-4.3 to 0.5) 0.03 -0.80 (-2.6 to 0.1) -0.94 (-2.8 to 0.5) -0.81 (-3.7 to 0.5) 0.90
DXR-MCI 0.40 (0.37–0.49) 0.37 (0.31–0.45) <0.01 0.41 (0.34–0.48) 0.39 (0.33–0.46) 0.32 (0.27–0.38) <0.01 0.40 (0.33–0.48) 0.37 (0.31–0.43) 0.33 (0.29–0.41) <0.01
DXR-MCI change (%) -0.89 (-5.5 to 0.0) -1.29 (-3.1 to -0.1) 0.66 -0.76 (-1.8 to 0.3) -1.34 (-3.4 to -0.4) -1.13 (-5.2 to -0.2) 0.06 -1.33 (-3.1 to -0.3) -1.20 (-3.2 to 0.3) -0.71 (-5.0 to 0.0) 0.74
  1. Digital X-ray radiogrammetry (DXR) bone mineral density (BMD), DXR metacarpal cortical index (MCI) and dual-energy X-ray absorptiometry (DXA) BMD assessed for levels of disease duration, for disease activity (disease activity score including 28 joints (DAS28)) and for physical function (Modified Health Assessment Questionnaire (MHAQ)) in rheumatoid arthritis patients. Data presented as the medians (interquartile range). *P values between subgroups.