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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therapy study

Figure 4

The effect of IL-1 receptor antagonist (IL-1Ra)-transfected cells on matrix metalloproteinase (MMP) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) expression in moderately degenerate intervertebral discs (IVDs). The graphs show the effects of medium alone, untransfected cells and cells transfected with IL-1Ra on the proportion of nucleus pulposus (NP) cells expressing the various enzymes by NP cells in human IVD explants at 48 hours and 14 days after injection of medium, medium containing non-transfected cells and medium containing transfected cells. Data expressed as mean percent + standard error of the mean.

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