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Table 1 Summary of patients investigated for CD4+CD28null T cells in synovial membrane biopsies

From: Skewed distribution of proinflammatory CD4+CD28nullT cells in rheumatoid arthritis

Patient Gender, age (years) Disease duration (years) Treatmenta Erosive disease CD3+ in synovial membraneb CD4+CD28null T cells
       Peripheral blood (%) Synovial fluid (%) n/T-cell infiltratec n/mm2 T-cell infiltratec
>5% CD4+CD28null T cells in peripheral blood
   1 Female, 69 1 P, M - ++ 18 6 3 35
   2 Female, 45 15 N, L + + 9.8 10.4 2.5 54
   3 Female, 67 2.75 N + ++ 7.6 6.5 5 47
   4 Female, 51 33 N, P + +++ 13 1.5 4.7 48
   5 Male, 74 26 N, P, E + ++ 8.6 2.7 0.8 5
   6 Male, 38 22 N, M, E + ++ 8 0.8 2 39
<1% CD4+CD28null T cells in peripheral blood
   7 Male, 45 13 N + + 0 0.4 1.3 53
   8 Male, 25 0.6 N, P, M - ++ 0 0.2 3 51
   9 Female, 60 Several years N, D - ++ 0 0.1 0 0
   10 Male, 41 1 P + +++ 0.4 0.8 4.5 67
   11 Female, 66 10 M + ++ 0.4 0.6 0 0
  1. aP, prednisolone; M, methotrexate; N, nonsteroidal anti-inflammatory drug; L, leflunomid; E, etanercept; D, depomedrol. bRelative size of infiltrating CD3+ cells in the synovial membrane specimen: +, <25% T cells in the tissue area; ++, approximately 50% T cells in the tissue area; +++, >75% T cells in the tissue area. cAverage numbers of CD4+CD28null T cells in one to five analysed infiltrates.