Skip to main content

Advertisement

Table 1 Effects of azothioprine, chloroquine, D-penicillamine, sodium aurothiomalate (gold salt) and methotrexate administration over 22 days on gait parameters of arthritic rats

From: Quantitative gait analysis as a method to assess mechanical hyperalgesia modulated by disease-modifying antirheumatoid drugs in the adjuvant-induced arthritic rat

  Day Stride length (cm) Stance time (s) Swing time (s)
Normal control rats 0 14.44 ± 0.40 5.512 ± 0.05 5.842 ± 0.09
  22 14.5 ± 0.34 5.53 ± 0.13 6.011 ± 0.87
Arthritic rats     
   Vehicle (saline) 0 15.33 ± 1.05 5.06 ± 0.01 7.12 ± 1.01
  22 6.52 ± 0.57 16.82 ± 0.08 15.32 ± 0.43
   Azothioprine (5 mg/kg/day) 0 13.66 ± 0.29 5.97 ± 0.110 7.24 ± 0.079
  22 13.16 ± 0.50 7.01 ± 0.091 6.57 ± 0.11
   Chloroquine (12.5 mg/kg/day) 0 14.28 ± 0.49 6.11 ± 0.33 6.82 ± 0.523
  22 14.01 ± 0.48 6.98 ± 0.055 7.51 ± 0.073
   D-Penicillamine (12.5 mg/kg/day) 0 14.95 ± 0.29 4.21 ± 0.017 6.54 ± 0.15
  22 8.59 ± 0.31 11.5 ± 0.091 10.01 ± 0.11
   Gold Salt (GS, 2.5 mg/kg/day) 0 15.89 ± 0.49 5.78 ± 0.33 6.72 ± 0.48
  22 14.98 ± 0.44 6.07 ± 0.055 5.98 ± 0.093
   Methotrexate (0.5 mg/kg/week) 0 16.01 ± 0.29 5.59 ± 0.017 5.83 ± 0.075
  22 12.79 ± 0.50 7.23 ± 0.09 7.21 ± 0.121
   Indomethacine(5 mg/kg/day) 0 14.22 ± 0.49 4.85 ± 0.33 6.07 ± 0.077
  22 14.01 ± 0.48 7.17 ± 0.055 8.22 ± 0.23
  1. Results expressed as the mean ± standard error (n = 6) on day 0 and day 22 of the experiment.