Table 1 Effects of azothioprine, chloroquine, D-penicillamine, sodium aurothiomalate (gold salt) and methotrexate administration over 22 days on gait parameters of arthritic rats

Normal control rats

0

14.44 ± 0.40

5.512 ± 0.05

5.842 ± 0.09

22

14.5 ± 0.34

5.53 ± 0.13

6.011 ± 0.87

Arthritic rats

   Vehicle (saline)

0

15.33 ± 1.05

5.06 ± 0.01

7.12 ± 1.01

22

6.52 ± 0.57

16.82 ± 0.08

15.32 ± 0.43

   Azothioprine (5 mg/kg/day)

0

13.66 ± 0.29

5.97 ± 0.110

7.24 ± 0.079

22

13.16 ± 0.50

7.01 ± 0.091

6.57 ± 0.11

   Chloroquine (12.5 mg/kg/day)

0

14.28 ± 0.49

6.11 ± 0.33

6.82 ± 0.523

22

14.01 ± 0.48

6.98 ± 0.055

7.51 ± 0.073

   D-Penicillamine (12.5 mg/kg/day)

0

14.95 ± 0.29

4.21 ± 0.017

6.54 ± 0.15

22

8.59 ± 0.31

11.5 ± 0.091

10.01 ± 0.11

   Gold Salt (GS, 2.5 mg/kg/day)

0

15.89 ± 0.49

5.78 ± 0.33

6.72 ± 0.48

22

14.98 ± 0.44

6.07 ± 0.055

5.98 ± 0.093

   Methotrexate (0.5 mg/kg/week)

0

16.01 ± 0.29

5.59 ± 0.017

5.83 ± 0.075

22

12.79 ± 0.50

7.23 ± 0.09

7.21 ± 0.121

   Indomethacine(5 mg/kg/day)

0

14.22 ± 0.49

4.85 ± 0.33

6.07 ± 0.077

22

14.01 ± 0.48

7.17 ± 0.055

8.22 ± 0.23