Figure 7

Variation in paw volume in rats with CIA treated with vehicle or IL-23 blockade. (a) Paw volumes of control rats, vehicle-treated rats with collagen-induced arthritis (CIA), and rats with CIA that were treated with anti-IL-23 antibody, from day 0 to day 21. Open squares, rats with CIA treated with vehicle; open circles, controls; filled triangles, rats with CIA treated with 3.0 μg of anti-IL-23 antibody; filled diamonds, rats with CIA treated with 6.0 μg of anti-IL-23 antibody. Means ± SD are shown. ^#P = 0.021 versus controls, ^##P = 0.021 versus controls, ^¶P = 0.014 versus vehicle, ^§P = 0.007 versus vehicle (Mann–Whitney U test). (b) Arthritis scores of control rats, vehicle-treated rats with CIA, and rats with CIA that were treated with anti-IL-23 antibody, from day 0 to day 28. Open squares, rats with CIA treated with vehicle; open circles, controls; filled triangles, rats with CIA treated with 3.0 μg of anti-IL-23 antibody; filled diamonds, rats with CIA treated with 6.0 μg of anti-IL-23 antibody. Means ± SD are shown. ^#P = 0.021 versus controls, ^##P = 0.021 versus controls (Mann–Whitney U test).