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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling

Figure 1

Histological appearance of knee joints injected with an adenovirus overexpressing bone morphogenetic protein-2 (BMP-2). Right knee joints were injected intra-articularly with Ad-BMP-2 or a control virus. Mice were injected with 35SO42- prior to knee joint isolation for histology on days 3, 7, or 21. Paraffin sections were stained with safranin O/fast green (a-d), prepared for autoradiography (e-h), and stained immunohistochemically for VDIPEN (i-l) or NITEGE (m-p). Controls displayed here are from day 3 (a,e,i,m). Cartilage of mice injected with Ad-BMP-2 appeared to have larger chondrocytes than controls (c,d). Proteoglycan synthesis had increased by stimulation with BMP-2 (f-h). BMP-2 stimulation also leads to increased VDIPEN staining (k) and NITEGE staining (q,p). Arrows point to intense staining around chondrocytes. FastG, fast green; SafO, safranin O.

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Arthritis Research & Therapy

ISSN: 1478-6362

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