Figure 4

PPI-2458 reduces joint destruction in chronic collagen-induced arthritis. Following onset of arthritis, mice were treated with either PPI-2458 (1.5 mg/kg every other day), soluble tumour necrosis factor receptor (sTNF-R)II (5 mg/kg every other day), or vehicle alone for 28 days. Hematoxylin and eosin sections were scored in a blinded manner for pannus formation, synovitis, bone and cartilage erosion. Representative images, with bar equivalent to 20 μm, are illustrated.