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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Cyclooxygenase inhibition lowers prostaglandin E2 release from articular cartilage and reduces apoptosis but not proteoglycan degradation following an impact load in vitro

Figure 4

Celecoxib and indomethacin reduced the percentage of impact-induced apoptotic chondrocytes following an impact load. Following loading (as described in Figure 3) and culture in the presence of celecoxib and indomethacin for 6 days, the percentage of apoptotic cells in frozen sections (8 μm) of articular cartilage explants was measured using the TUNEL assay. Mean values (± standard deviation, n = 12). Asterisks denote significant differences between the groups as shown. (*p ≤ 0.05).

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Arthritis Research & Therapy

ISSN: 1478-6362

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