Figure 1From: The role of aldosterone blockade in murine lupus nephritisEffect of spironolactone on the development of nephrotic range proteinuria. The age at onset of nephrotic range proteinuria was compared between treatment groups. At the 36-week time point, 70.8% of the control mice had nephrotic proteinuria (as opposed to 51.3% and 48.6% of the mice treated with 25 mg/kg per day and 50 mg/kg per day, respectively). Sixteen animals were included in each group at the start of the study. P = 0.331, control versus spironolactone 50 mg/kg per day.Back to article page