Groups | IL-1 | TNF-α | VEGF | bFGF | MCP-1 |
---|
Normal controls | 0.23 ± 0.20 | 0.13 ± 0.07 | 1.39 ± 0.01 | 0.41 ± 0.18 | 0.26 ± 0.14 |
AIA controls | 1.40 ± 0.29* | 1.19 ± 0.19* | 3.40 ± 1.05* | 5.24 ± 0.35* | 1.05 ± 0.18* |
AIA + ROSI 10 | 0.98 ± 0.06 | 1.39 ± 0.16 | 3.79 ± 0.28 | 4.59 ± 0.77 | 1.51 ± 0.22 |
AIA + PIO 30 | 0.66 ± 0.16# | 0.37 ± 0.11# | 4.67 ± 0.21 | 2.18 ± 0.61# | 1.51 ± 0.21 |
- PPAR, peroxisome proliferator-activated receptor; AIA, adjuvant-induced arthritis; ROSI 10, rosiglitazone 10 mg/kg/day; PIO 30, pioglitazone 30 mg/kg/day; VEGF, vascular endothelial growth factor; bFGF, basic fibroblast growth factor; MCP-1, monocyte chemotactic protein-1. Data are expressed as means ± SEM of mRNAs of the gene of interest over L27 mRNA (n = 3 representative samples per group).
- *, P < 0.05 compared with normal controls; #, P < 0.05 compared with AIA controls (ANOVA and Fisher's PLSD test).