From: Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitrostudy
Functional annotation: gene title (gene symbol) | Accession no. | Chondrocyte mean fold change in expression (GCOS and RMA analysis) | Chondrocyte mean signal intensity (GCOS and RMA analysis) | ||
---|---|---|---|---|---|
 |  | RASFsn versus NDSFsn stimulation | RASFsn stimulation | NDSFsn stimulation | No stimulation |
Inflammation | Â | Â | Â | Â | Â |
   Cyclooxygenase-2 (COX-2) | NM_000963.1 | 2.09 | 4,474.90 | 1,793.25 | 108.4 |
   Hydroxysteroid (11-β) dehydrogenase 1 (HSD11B1) | NM_005525 | 2.41 | 2,693.41 | 955.89 | 1,263.95 |
   Adenosine A2A receptor (ADORA2A) | NM_000675 | 4.73 | 249.59 | 40.13 | 27.33 |
   Phospholipase A2, group IIA (PLA2G2A) | NM_000300 | -2.38 | 152.32 | 347.63 | 787.68 |
   Steroid sulfatase (STS) | AI122754 | -3.17 | 48.36 | 132.73 | 412.43 |
   Latexin (LXN) | NM_020169 | -5.82 | 122.35 | 677.95 | 610.08 |
NF-κB signaling pathway |  |  |  |  |  |
   Interleukin-1 receptor antagonist (IL1RN) | U65590 | 2.10 | 1,143.23 | 278.77 | 48.83 |
   Receptor-interacting serine/threonine kinase 2 (RIPK2) | AF064824.1 | 2.12 | 1,190.60 | 539.58 | 22.65 |
   Toll-like receptor 2 (TLR2) | NM_003264 | 2.25 | 859.07 | 322.16 | 57.30 |
   Spermine synthase (SMS) | NM_004595 | 2.90 | 165.10 | 58.99 | 40.10 |
   Bcl2-related protein A1 (BCL2A1) | NM_004049 | 4.90 | 573.95 | 94.87 | 14.63 |
   Ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2) | L35594.1 | -3.26 | 810.00 | 2,175.34 | 1,273.98 |
   Thioredoxin interacting protein (TXNIP) | AI439556 | -3.50 | 223.27 | 622.39 | 670.70 |
Cytokines/chemokines and receptors | Â | Â | Â | Â | Â |
   Met proto-oncogene (HGF receptor) (MET) | J02958.1 | 2.02 | 823.83 | 333.01 | 74.13 |
   Chemokine (C-X-C motif) ligand 1 (Groα) | NM_001511.1 | 2.08 | 1,414.49 | 478.28 | 28.05 |
   Chemokine (C-X-C motif) ligand 2 (Groβ) | M57731.1 | 2.51 | 761.47 | 237.34 | 10.08 |
   Interleukin 8 (IL8) | AF043337.1 | 3.16 | 5,688.87 | 1,393.65 | 38.28 |
   Chemokine (C-X-C motif) ligand 3 (Groγ) | NM_002090 | 3.78 | 368.84 | 58.19 | 16.68 |
   Chemokine (C-C motif) ligand 20 (MIP-3β) | NM_004591.1 | 5.25 | 2,028.88 | 270.12 | 14.65 |
   Granulocyte colony-stimulating factor 3 (CSF3) | NM_000759 | 5.61 | 180.70 | 51.59 | 45.18 |
   Chemokine (C-X-C motif) receptor 4 (CXCR4) | AJ224869 | 5.66 | 180.71 | 27.87 | 16.10 |
   Interleukin-23, α subunit p19 (IL-23A) | NM_016584 | 11.00 | 674.98 | 43.00 | 39.33 |
Immune response | Â | Â | Â | Â | Â |
   Guanylate binding protein 1, interferon-inducible (GBP1) | BC002666 | 2.10 | 450.29 | 198.92 | 175.15 |
   2',5'-Oligoadenylate synthetase-related protein p30 (OASL) | AF063612.1 | 2.38 | 287.65 | 98.51 | 115.65 |
   Interferon-induced protein 44 (IFI44) | NM_006417 | 2.40 | 480.29 | 124.50 | 238.30 |
   Lymphocyte antigen 6 complex, locus E (LY6E) | NM_002346.1 | 2.45 | 569.07 | 236.97 | 305.15 |
   Interferon regulatory factor 7 (IRF7) | NM_004030.1 | 2.48 | 286.31 | 93.75 | 84.93 |
   Interferon-α inducible protein (IFI-6–16) | NM_022873 | 2.60 | 550.64 | 158.67 | 138.78 |
   Interferon-stimulated gene 20 kDa (ISG20) | U88964 | 2.61 | 434.38 | 153.79 | 47.20 |
   Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) | NM_001549 | 2.69 | 527.75 | 137.20 | 290.03 |
   Pentaxin-related gene, rapidly induced by IL-1β (PTX3) | NM_002852 | 2.72 | 340.14 | 120.25 | 209.70 |
   Hect domain and RLD 6 (HERC6) | NM_017912.1 | 3.04 | 302.12 | 65.85 | 117.53 |
   Myxovirus resistance 1, interferon-inducible protein p78 (MX1) | NM_002462 | 3.09 | 1,355.03 | 312.35 | 557.75 |
   Hect domain and RLD 5 (HERC5) | NM_016323 | 3.30 | 608.65 | 160.90 | 141.13 |
   2',5'-Oligoadenylate synthetase 1 (OAS1) | NM_002534 | 4.08 | 264.81 | 55.57 | 70.00 |
   Interferon-α inducible protein, clone IFI-15K (ISG15) | NM_005101.1 | 4.62 | 1,943.31 | 296.19 | 603.98 |
   Interferon-induced protein 44-like (IFI44L) | NM_006820.1 | 4.64 | 691.99 | 84.63 | 138.85 |
   Interferon-α inducible protein 27 (IFI27) | NM_005532 | 5.07 | 814.69 | 119.31 | 154.15 |
   Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) | NM_001548 | 5.25 | 774.38 | 94.09 | 361.93 |
   Viperin (cig5) | AI337069 | 7.14 | 423.91 | 34.32 | 45.65 |
   Collectin sub-family member 12 (COLEC12) | NM_030781 | -2.22 | 648.64 | 1,347.08 | 2,518.28 |
Cell proliferation and differentiation | Â | Â | Â | Â | Â |
   WNT1 inducible signaling pathway protein 2 (WISP2) | NM_003881 | -2.97 | 206.25 | 508.11 | 4,898.73 |
   Inhibitor of DNA binding 3, dominant negative HLH protein (ID3) | NM_002167.1 | -3.74 | 240.35 | 715.78 | 1,465.13 |
   Inhibitor of DNA binding 1, dominant negative HLH protein (ID1) | D13889.1 | -4.04 | 742.79 | 2,479.99 | 2,376.33 |
   Retinoic acid receptor responder 1 (RARRES1) | NM_002888 | -6.10 | 115.83 | 538.71 | 152.20 |
   Fibroblast growth factor 1, acidic (FGF1) | X59065 | -8.51 | 82.49 | 513.38 | 70.23 |
Matrix synthesis | Â | Â | Â | Â | Â |
   Laminin, β3 (LAMB3) | L25541.1 | 3.05 | 636.22 | 196.21 | 63.28 |
   EGF-containing fibulin-like ECM protein 1 (EFEMP1) | NM_004105 | -3.14 | 170.34 | 458.87 | 331.85 |
   Thrombospondin 2 (THBS2) | NM_003247 | -3.28 | 181.13 | 489.40 | 483.68 |
   Spondin 1, extracellular matrix protein (SPON1) | AB051390.1 | -4.4 | 56.04 | 167.4 | 69.60 |
   Chondroitin sulfate proteoglycan 2 (CSPG2) | NM_004385 | -4.53 | 235.72 | 670.67 | 456.13 |
   Cartilage oligomeric matrix protein (COMP) | NM_000095 | -5.08 | 156.77 | 655.37 | 308.43 |
Others | Â | Â | Â | Â | Â |
   Metallothionein 1E (MT1E) | BF217861 | 2.03 | 1,111.45 | 554.65 | 708.38 |
   Solute carrier family 7 member 11 (SLC7A11) | AB040875.1 | 2.16 | 692.03 | 300.52 | 87.70 |
   Deafness, autosomal dominant 5 (DFNA5) | NM_004403 | 2.63 | 1,133.05 | 379.29 | 288.20 |
   Phosphoglycerate dehydrogenase (PHGDH) | NM_006623 | 2.63 | 171.02 | 60.04 | 138.58 |
   Paired immunoglobin-like type 2 receptor α (PILRA) | AJ400843.1 | 2.82 | 131.89 | 32.78 | 23.75 |
   Calmegin (CLGN) | NM_004362.1 | 3.20 | 356.58 | 87.11 | 19.30 |
   Neuromedin B (NMB) | NM_021077 | 3.34 | 1,163.69 | 261.33 | 177.98 |
   Regulator of G-protein signaling 4 (RGS4) | NM_005613.3 | 3.92 | 136.81 | 22.34 | 42.05 |
   Phosphoinositide-3-kinase, polypeptide 1 (PIK3R1) | AI679268 | -3.03 | 105.59 | 262.02 | 182.88 |
   Deiodinase, iodothyronine, type II (DIO2) | U53506.1 | -3.10 | 71.24 | 193.23 | 122.88 |
   DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 (DDX10) | NM_004398.2 | -3.22 | 223.36 | 681.54 | 252.50 |
   CDK5 regulatory subunit associated protein 2 (CDK5RAP2) | NM_018249 | -3.28 | 250.80 | 660.54 | 349.68 |
   Cullin 4B (CUL4B) | AV694732 | -3.41 | 130.55 | 381.94 | 83.58 |
   Pyruvate dehydrogenase kinase, isoenzyme 4 (PDK4) | NM_002612.1 | -3.65 | 54.75 | 179.75 | 72.75 |
   ATP-binding cassette, sub-family A (ABC1), member 8 (ABCA8) | NM_007168 | -3.83 | 81.80 | 202.99 | 141.58 |
   Adlican (DKFZp564I1922) | AF245505.1 | -4.90 | 145.69 | 486.56 | 1,835.15 |