Volume 3 Supplement 2

21st European Workshop for Rheumatology Research

Open Access

Dendritic cell subsets in rheumatoid arthritis

  • K Summers1,
  • J O'Donnell1 and
  • A Rothwell2
Arthritis Research & Therapy20013(Suppl 2):P067

https://doi.org/10.1186/ar236

Received: 15 January 2001

Published: 26 January 2001

Distinct myeloid DC and lymphoid DC subsets have been described, which regulate the nature and magnitude of immune responses. Therefore DC function must be carefully regulated, otherwise inappropriate responses may result in such chronic inflammatory diseases as rheumatoid arthritis (RA). In this study the composition and activation state of DC subsets was compared between autologous blood, synovial fluid and synovial tissue of RA patients using 4-colour flow cytometry. Preliminary results indicated that RA blood and normal blood had a similar ratio of DC subsets, both of which exist in a relatively inactivated state. In contrast, myeloid DC were predominant in RA synovial fluid and synovial tissue. In synovial tissue these myeloid DC were more highly activated and localized to lymphoid aggregates. Lymphoid DC were scarce in both synovial fluid and synovial tissue.

Conclusion

These results suggest that myeloid DC play a key role in the pathogenesis of RA and supports the view that RA is predominantly a Th1-mediated disease.

Authors’ Affiliations

(1)
Department of Immunology, Christchurch Hospital
(2)
Department of Orthopaedic Surgery, Christchurch Hospital

Copyright

© BioMed Central Ltd 2001

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