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Table 2 Sensitivity, specificity and positive predictive value of anti-MCV and anti-CCP for clinical diagnosis of RA in early arthritis patients

From: Antibodies to mutated citrullinated vimentin and disease activity score in early arthritis: a cohort study

Antibody Sensitivity (%; 95% CI) Specificity (%; 95% CI) PPV (%)
Anti-CCP2 level ≥ 25 U/ml 55.3 (46.1 to 64.2) 92.1 (77.5 to 97.9) 95.8
Anti-MCV level ≥ 20 U/ml 59.3 (50.1 to 67.9) 92.3 (78.0 to 97.9) 96.1
  1. Shown are the sensitivity, specificity and positive predictive value (PPV) of anti-mutated citrullinated vimentin (anti-MCV) and anti-second-generation cyclic citrullinated peptide (anti-CCP2) for the clinical diagnosis of rheumatoid arthritis (RA) in early arthritis, using cut off values recommended by the manufacturers of the tests. A total of 162 patient with early arthritis were included in the analysis. CI, confidence interval.