Event and drug
|
Relative risk
|
Additional events per 1,000
|
Additional deaths per 1,000
|
Frequency (1 in)
|
---|
Gastrointestinal bleeding (background rate 2.2 per 1,000)
|
Ibuprofen
|
1.9
|
1.98
|
0.20
|
5,051
|
Naproxen
|
4.0
|
6.60
|
0.66
|
1,515
|
Diclofenac
|
3.3
|
5.06
|
0.51
|
1,976
|
All NSAIDs
|
4.2
|
7.04
|
0.70
|
1,420
|
Celecoxib
|
1.1
|
0.22
|
0.02
|
45,455
|
Rofecoxib
|
2.0
|
2.20
|
0.22
|
4,545
|
Myocardial infarction (background rate 8.2 per 1,000)
|
Ibuprofen
|
1.07
|
0.57
|
0.17
|
5,807
|
Naproxen
|
0.98
|
-0.16
|
-0.05
|
-20,325
|
Diclofenac
|
1.44
|
3.61
|
1.08
|
924
|
All NSAIDs
|
1.09
|
0.74
|
0.22
|
4,517
|
Celecoxib
|
0.96
|
-0.33
|
-0.10
|
-10,163
|
Rofecoxib
|
1.26
|
2.13
|
0.64
|
1,563
|
- Any dose of drug was allowed in the data, and the table additionally shows the rate and frequency of additional events. The calculations used a mortality rate of 10% for gastrointestinal bleeding and 30% for cardiovascular events. NSAID, non-steroidal anti-inflammatory drug; coxib, cyclooxygenase-2 inhibitor.