Common interleukin-6promoter variants associate with the more severe forms of distal interphalangeal osteoarthritis

Table 1 Linkage disequilibrium measures between the studied IL-6 promoter single nucleotide polymorphisms

Measure	rs1800797 and rs1800796	rs1800797 and rs1800795	rs1800796 and rs1800795
D'	1.0 (0.78–1.0)	0.968 (0.94–0.99)	1.0 (0.78–1.0)
LOD	7.53	184.12	7.79
r ²	0.045	0.885	0.048
Haplotypes	AG 54.0%	AC 53.3%	GC 55.5%
	GC 3.7%	GC 2.2%	CG 3.7%
	GG 42.3%	GG 43.8%	GG 40.8%
		AG 0.7%

D' – statistical measure of linkage disequilibrium (D' = 1 is known as complete linkage). The numbers in parentheses indicate 95% confidence intervals for D'. The lod score (LOD) serves as a test of the null hypothesis of free recombination versus the alternative hypothesis of linkage. LOD >3 is traditionally regarded as evidence for linkage.
r2 is a correlation coefficient between pairs of loci.

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