Skip to main content

Table 1 Linkage disequilibrium measures between the studied IL-6 promoter single nucleotide polymorphisms

From: Common interleukin-6promoter variants associate with the more severe forms of distal interphalangeal osteoarthritis

Measure rs1800797 and rs1800796 rs1800797 and rs1800795 rs1800796 and rs1800795
D' 1.0 (0.78–1.0) 0.968 (0.94–0.99) 1.0 (0.78–1.0)
LOD 7.53 184.12 7.79
r 2 0.045 0.885 0.048
Haplotypes AG 54.0% AC 53.3% GC 55.5%
  GC 3.7% GC 2.2% CG 3.7%
  GG 42.3% GG 43.8% GG 40.8%
   AG 0.7%  
  1. D' – statistical measure of linkage disequilibrium (D' = 1 is known as complete linkage). The numbers in parentheses indicate 95% confidence intervals for D'. The lod score (LOD) serves as a test of the null hypothesis of free recombination versus the alternative hypothesis of linkage. LOD >3 is traditionally regarded as evidence for linkage.
  2. r2 is a correlation coefficient between pairs of loci.