Table 4 Multivariate model for cardiovascular morbidity in the QUEST-RA study

1.04 (1.03–1.06)^b

1.05 (1.03–1.07)^b

1.04 (1.01–1.06)^c

0.49 (0.36–0.66)^b

0.45 (0.31–0.66)^b

0.55 (0.32–0.94)^c

0.95 (0.68–1.33)

0.95 (0.64–1.41)

0.90 (0.46–1.73)

1.33 (1.00–1.78)

1.28 (0.92–1.80)

1.60 (0.91–2.84)

1.95 (1.44–2.63)^b

1.85 (1.29–2.64)^c

2.23 (1.28–3.90)^c

2.41 (1.78–3.27)^b

2.16 (1.50–3.10)^b

3.24 (1.86–5.65)^b

1.34 (0.92–1.96)

1.05 (0.65–1.69)

2.20 (1.18–4.09)^c

1.56 (1.16–2.12)^c

1.46 (1.01–2.11)^d

1.88 (1.10–3.22)^c

1.16 (0.81–1.66)

1.52 (1.01–2.27)^d

0.57 (0.25–1.28)

0.93 (0.67–1.30)

1.11 (0.75–1.65)

0.61 (0.33–1.10)

Myocardial infarction hazard ratio (95% CI)

All countries

Countries with high prevalence

Countries with low prevalence

1.05 (1.02–1.08)^c

1.04 (1.01–1.08)^c

1.06 (1.00–1.13)^c

0.46 (0.27–0.80)^c

0.55 (0.29–1.06)

0.37 (0.13–1.04)

0.68 (0.36–1.31)

0.68 (0.31–1.48)

0.82 (0.23–2.91)

2.26 (1.29–3.97)^c

2.26 (1.17–4.37)^c

2.13 (0.71–6.35)

1.45 (0.83–2.53)

1.10 (0.57–2.15)

2.19 (0.72–6.71)

3.51 (1.98–6.21)^b

3.51 (1.80–6.84)^b

4.34 (1.41–13.33)^c

1.18 (0.59–2.38)

1.27 (0.56–2.90)

1.01 (0.24–4.29)

3.20 (1.74–5.90)^b

2.47 (1.22–4.99)^c

12.14 (2.50–59.05)^c

0.74 (0.34–1.62)

0.59 (0.22–1.57)

1.36 (0.37–5.01)

0.88 (0.46–1.65)

0.96 (0.45–2.07)

0.87 (0.24–3.12)

Stroke hazard ratio (95% CI)

All countries

Countries with high prevalence

Countries with low prevalence

1.02 (0.99–1.05)

1.03 (1.00–1.06)

0.99 (0.93–1.05)

0.59 (0.31–1.12)

0.66 (0.31–1.42)

0.37 (0.10–1.39)

0.95 (0.45–2.00)

0.88 (0.38–2.06)

2.67 (0.40–17.71)

1.41 (0.77–2.58)

1.43 (0.69–2.94)

1.31 (0.40–4.30)

2.81 (1.49–5.30)^c

2.95 (1.43–6.11)^c

2.37 (0.61–9.20)

1.18 (0.60–2.31)

0.69 (0.27–1.76)

3.69 (1.16–11.78)^c

2.23 (1.12–4.44)^d

1.70 (0.71–4.07)

4.63 (1.31–16.40)^c

1.66 (0.89–3.09)

1.74 (0.82–3.69)

1.31 (0.37–4.63)

0.72 (0.31–1.68)

0.77 (0.28–2.08)

0.56 (0.11–2.69)

1.01 (0.50–2.03)

1.30 (0.59–2.87)

0.52 (0.13–2.09)