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Table 4 Association of demographic, clinical, and laboratory characteristics and MBL2 genotype expression groups: oligoarthritis

From: Mannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort study

Characteristic MBL genotype expression groups    P a P b
  High (n = 77) Medium (n = 48) Low (n = 26)   
Demographic variables      
   Males 22 (29%) 10 (21%) 8 (31%) NS NS
   Age (years) at onset 6.6 (3.4 to 10.6) 8.7 (2.6 to 12.1) 6.6 (2.9 to 12.6) NS NS
   Disease duration (years) at follow up 14.5 (13.6 to 15.9) 15.1 (13.2 to 16.1) 15.3 (14.1 to 16.4) NS NS
Clinical variables     NS NS
   Cumulative affected joints 3 (2 to 6) 4 (2 to 6) 2 (2 to 4) NS NS
   Actively involved joints 0 (0 to 1) 0 (0 to 1) 0 (0 to 0) NS NS
   Affected joints 1 (0 to 3) 1 (0 to 2) 1 (0 to 3) NS NS
   Arthritis severity index 2 (0 to 6) 2 (0 to 5) 1.5 (0 to 5) NS NS
   Physician global assessment 1 (1 to 2) 1 (1 to 2) 1 (1 to 2) NS NS
   Childhood Health Assessment Questionnaire score 0.0 (0.0 to 0.3) 0.0 (0.0 to 0.1) 0.0 (0.0 to 0.4) NS NS
   Patients with uveitis 12 (16%) 16 (33%) 6 (23%) NS NS
   Remission status at follow up     0.02 0.01
Current remission 43 (56%) 26 (54%) 21 (81%)   
Active, but previous remission 27 (35%) 13 (27%) 1 (4%)   
Continuously active 7 (9%) 9 (19%) 4 (15%)   
Radiographic erosions grade III to IV 11 (14%) 8 (17%) 2 (8%) NS NS
Laboratory variables     NS NS
   Erythrocyte sedimentation rate (mm/hour) 6 (4 to 11) 8 (5 to 13) 5 (4 to 11) NS NS
   C-reactive protein (mg/l) 5 (1 to 5) 5 (3 to 6) 5 (5 to 9) <0.01 0.01
   Antinuclear antibody positivity 33 (43%) 18 (38%) 11 (42%) NS NS
   IgM-rheumatoid factor positivity 0 0 0 - -
  1. Included in this analysis are 151 patients with juvenile oligoarthritis. Values are expressed as number (%) or, for continuous variables, as median (interquartile range). aComparison of the high, medium and low genotype expression groups by means of the two-sided Fisher's exact test and Kruskal-Wallis test. bComparison of the high and medium genotype group versus the low genotype expression group by means of the two-sided Fisher's exact test and Mann-Whitney U-test. NS, not significant.