Analysis of soluble tissue factor-induced inflammation in protease activated receptor-deficient mice. Soluble tissue factor (1 μg) was injected into the footpad of mice with individual deficiency for one of the four different protease activated receptors (PARs). (a) PAR-1-deficient mice. (b) PAR-2-deficient mice. (c) PAR-3-deficient mice. (d) PAR-4-deficient mice. In each experiment, footpad swelling was assessed in the PAR-deficient mice and their littermates (+/+ or +/-) as controls.