Gene | Genotype/allele | NHS blood (219 matched pairs) | NHS cheek cell (169 matched pairs) | NHSII blood (49 matched pairs) | |||
---|---|---|---|---|---|---|---|
 |  | Cases | Controls | Cases | Controls | Cases | Controls |
PTPN22 a | Genotype | Â | Â | Â | Â | Â | Â |
 |    CC | 160 (74%) | 178 (82%) | 125 (77%) | 131 (80%) | 37 (79%) | 44 (94%) |
 |    CT | 50 (23%) | 38 (18%) | 30 (18%) | 31 (19%) | 7 (15%) | 3 (6%) |
 |    TT | 5 (2%) | 1 (0.5%) | 8 (5%) | 1 (1%) | 3 (6%) | 0 (0%) |
 |    Missing | 4 | 2 | 6 | 6 | 2 | 2 |
 |    Pe | 0.08 |  | 0.07 |  | 0.06 |  |
 | Allele |  |  |  |  |  |  |
 |    C | 370 (86%) | 394 (91%) | 280 (86%) | 293 (90%) | 81 (86%) | 91 (97%) |
 |    T | 60 (14%) | 40 (9%) | 46 (14%) | 33 (10%) | 13 (14%) | 3 (3%) |
 |    Pf | 0.03 |  | 0.12 |  | 0.009 |  |
CTLA-4 b | Genotype | Â | Â | Â | Â | Â | Â |
 |    AA | 35 (17%) | 46 (22%) | 40 (25%) | 29 (18%) | 7 (15%) | 12 (25%) |
 |    AG | 106 (50%) | 96 (45%) | 69 (42%) | 80 (50%) | 26 (54%) | 19 (40%) |
 |    GG | 71 (33%) | 70 (33%) | 54 (33%) | 51 (32%) | 15 (31%) | 17 (35%) |
 |    Missing | 7 | 7 | 6 | 9 | 1 | 1 |
 |    Pf | 0.37 |  | 0.27 |  | 0.28 |  |
 | Allele |  |  |  |  |  |  |
 |    A | 176 (42%) | 188 (44%) | 149 (46%) | 138 (43%) | 40 (42%) | 43 (45%) |
 |    G | 248 (58%) | 236 (56%) | 177 (54%) | 182 (57%) | 56 (58%) | 53 (55%) |
 |    Pf | 0.41 |  | 0.51 |  | 0.66 |  |
PADI-4 c | Genotype | Â | Â | Â | Â | Â | Â |
 |    GG | 76 (35%) | 76 (36%) | 57 (35%) | 64 (39%) | 22 (45%) | 18 (38%) |
 |    GA | 107 (49%) | 101 (47%) | 68 (41%) | 73 (44%) | 16 (33%) | 21 (45%) |
 |    AA | 34 (16%) | 37 (17%) | 39 (24%) | 28 (17%) | 11 (22%) | 8 (17%) |
 |    Missing | 2 | 5 | 5 | 4 | 0 | 2 |
 |    Pf | 0.87 |  | 0.30 |  | 0.47 |  |
 | Allele |  |  |  |  |  |  |
 |    G | 259 (60%) | 253 (59%) | 182 (55%) | 201 (61%) | 60 (61%) | 57 (61%) |
 |    A | 175 (40%) | 175 (41%) | 146 (45%) | 129 (39%) | 38 (39%) | 37 (39%) |
 |    Pf | 0.87 |  | 0.16 |  | 0.93 |  |
HLA-SE d | 0 copy | 84 (38%) | 122 (56%) | 99 (60%) | 114 (70%) | 23 (47%) | 30 (63%) |
 | 1 copies | 99 (45%) | 83 (38%) | 52 (32%) | 40 (24%) | 17 (35%) | 17 (35%) |
 | 2 copies | 36 (16%) | 14 (6%) | 13 (8%) | 10 (6%) | 9 (18%) | 1 (2%) |
 | Missing | 0 | 0 | 5 | 5 | 0 | 1 |
 | P f | 0.0001 |  | 0.22 |  | 0.03 |  |