Table 3 Genotype and allele frequencies of C/T transition SNP (rs4720262) of the TXNDC3 gene in Chinese and Japanese populations
Group | Number of subjects | Genotype count (frequency) | Allele count (frequency) | |||
|---|---|---|---|---|---|---|
| Â | Â | CC | CT | TT | C | T |
Chinese patients with knee OA | ||||||
All | 469 | 398 (0.849) | 65 (0.139) | 6 (0.012) | 861 (0.918) | 77 (0.082) |
Female | 323 | 274 (0.848) | 45 (0.139) | 4 (0.013) | 593 (0.918) | 53 (0.082) |
Male | 146 | 124 (0.849) | 20 (0.137) | 2 (0.014) | 268 (0.918) | 24 (0.082) |
Chinese control individuals | ||||||
All | 486 | 394 (0.811) | 90 (0.185) | 2 (0.004) | 878 (0.903) | 94 (0.097) |
Female | 316 | 257 (0.813) | 59 (0.187) | 0 | 573 (0.907) | 59 (0.093) |
Male | 170 | 137 (0.806) | 31 (0.182) | 2 (0.012) | 305 (0.897) | 35 (0.103) |
Japanese patients with knee OA | ||||||
All | 376 | 299 (0.795) | 74 (0.197) | 3 (0.008) | 672 (0.894) | 80 (0.106) |
Female | 327 | 257 (0.786) | 68 (0.208) | 2 (0.006) | 582 (0.890) | 72 (0.110) |
Male | 49 | 42 (0.857) | 6 (0.122) | 1 (0.021) | 90 (0.918) | 8 (0.082) |
Japanese control individuals | ||||||
All | 374 | 279 (0.746) | 84 (0.225) | 11 (0.029) | 642 (0.858) | 106 (0.142) |
Female | 116 | 89 (0.767) | 24 (0.207) | 3 (0.026) | 202 (0.871) | 30 (0.129) |
Male | 258 | 190 (0.736) | 60 (0.233) | 8 (0.031) | 440 (0.853) | 76 (0.147) |