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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity

Figure 4

Gelatinase activity is attenuated but not abrogated during insulin growth factor (IGF) stimulation. Gelatinase activity in conditioned medium from bovine articular cartilage explants was investigated by zymography. Lane 1 shows standards for matrix metalloproteinase (MMP)-9 + MMP-2. Conditioned medium at the end of each catabolic culture period (7, 11, or 17 days) was used as a reference (lanes 2 to 4). Conditioned medium from cultures treated with IGF (lanes 8 to 10) or vehicle (lanes 5 to 7) 7 days after the catabolic period was analyzed. Compared with vehicle and baseline measurements, IGF only attenuated MMP production and activation.

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Arthritis Research & Therapy

ISSN: 1478-6362

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