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Table 5 Genotype frequencies of IL-4/IL-13 variants and production of autoantibodies

From: Lack of association or interactions between the IL-4, IL-4Rα and IL-13 genes, and rheumatoid arthritis

Gene SNP Genotypes Anti-CCP statusa RF statusa
    Positive (n) Negative (n) OR (95% CI) P Positive (n) Negative (n) OR (95% CI) P
IL-13 rs1800925 TT 17 8 0.6 (0.3–1.8) 0.3b 16 7 1.0 (0.4–3.0) 1.0b
   CT 207 59 1.1 (0.7–1.5) 0.8 170 82 0.9 (0.7–1.3) 0.6
   CC 458 138 1.0   387 171 1.0  
  rs1295686 TT 20 6 1.0 (0.4–3.0) 1.0b 16 10 0.7 (0.3–1.8) 0.5b
   CT 192 54 1.0 (0.7–1.5) 0.8 161 72 1.0 (0.7–1.4) 1.0
   CC 439 128 1.0   367 165 1.0  
IL-4 rs2227284 AA 42 14 0.8 (0.4–1.7) 0.5 33 21 0.7 (0.4–14) 0.3
   AC 232 74 0.8 (0.6–1.2) 0.3 202 89 1.0 (0.8–1.5) 0.8
   CC 419 113 1.0   338 156 1.0  
  rs2243263 CC 5 3 0.5 (0.09–3.1) 0.4b 5 3 0.8 (0.1–5.0) 0.7b
   AC 102 38 0.8 (0.5–1.2) 0.2 89 44 0.9 (0.6–1.4) 0.2
   AA 568 160 1.0   465 213 1.0  
  rs2243267 CC 17 1 5.2 (0.8–218.9) 0.09b 13 4 1.5 (0.4–6.2) 0.6b
   CG 167 48 1.1 (0.7–1.6) 0.9 142 64 1.0 (0.7–1.4) 1.0
   GG 503 154 1.0   422 190 1.0  
IL-4R rs1805010 GG 150 43 0.8 (0.5–1.4) 0.4 122 59 0.8 (0.5–1.3) 0.3
   AG 341 109 0.8 (0.5–1.2) 0.2 288 136 0.8 (0.6–1.2) 0.3
   AA 196 50 1.0   165 64 1.0  
  rs1801275 AA 31 5 2.0 (0.7–6.6) 0.2 26 9 1.4 (0.6–3.4) 0.6
   AG 241 71 1.1 (0.8–1.5) 0.7 197 92 1.0 (0.7–1.4) 1.0
   GG 416 131 1.0   351 165 1.0  
  1. aThe presence of anti-cyclic citrullinated peptide (anti-CCP) and rheumatoid factor (RF) was compared for each single nucleotide polymorphism (SNP) with reference to the commonest genotype. bBy Fisher's exact test for association. CI, confidence interval; OR, odds ratio.