Lack of association or interactions between the IL-4, IL-4Rα and IL-13 genes, and rheumatoid arthritis

Table 5 Genotype frequencies of IL-4/IL-13 variants and production of autoantibodies

Gene	SNP	Genotypes	Anti-CCP status^a				RF status^a
			Positive (n)	Negative (n)	OR (95% CI)	P	Positive (n)	Negative (n)	OR (95% CI)	P
IL-13	rs1800925	TT	17	8	0.6 (0.3–1.8)	0.3^b	16	7	1.0 (0.4–3.0)	1.0^b
		CT	207	59	1.1 (0.7–1.5)	0.8	170	82	0.9 (0.7–1.3)	0.6
		CC	458	138	1.0		387	171	1.0
	rs1295686	TT	20	6	1.0 (0.4–3.0)	1.0^b	16	10	0.7 (0.3–1.8)	0.5^b
		CT	192	54	1.0 (0.7–1.5)	0.8	161	72	1.0 (0.7–1.4)	1.0
		CC	439	128	1.0		367	165	1.0
IL-4	rs2227284	AA	42	14	0.8 (0.4–1.7)	0.5	33	21	0.7 (0.4–14)	0.3
		AC	232	74	0.8 (0.6–1.2)	0.3	202	89	1.0 (0.8–1.5)	0.8
		CC	419	113	1.0		338	156	1.0
	rs2243263	CC	5	3	0.5 (0.09–3.1)	0.4^b	5	3	0.8 (0.1–5.0)	0.7^b
		AC	102	38	0.8 (0.5–1.2)	0.2	89	44	0.9 (0.6–1.4)	0.2
		AA	568	160	1.0		465	213	1.0
	rs2243267	CC	17	1	5.2 (0.8–218.9)	0.09^b	13	4	1.5 (0.4–6.2)	0.6^b
		CG	167	48	1.1 (0.7–1.6)	0.9	142	64	1.0 (0.7–1.4)	1.0
		GG	503	154	1.0		422	190	1.0
IL-4R	rs1805010	GG	150	43	0.8 (0.5–1.4)	0.4	122	59	0.8 (0.5–1.3)	0.3
		AG	341	109	0.8 (0.5–1.2)	0.2	288	136	0.8 (0.6–1.2)	0.3
		AA	196	50	1.0		165	64	1.0
	rs1801275	AA	31	5	2.0 (0.7–6.6)	0.2	26	9	1.4 (0.6–3.4)	0.6
		AG	241	71	1.1 (0.8–1.5)	0.7	197	92	1.0 (0.7–1.4)	1.0
		GG	416	131	1.0		351	165	1.0

^aThe presence of anti-cyclic citrullinated peptide (anti-CCP) and rheumatoid factor (RF) was compared for each single nucleotide polymorphism (SNP) with reference to the commonest genotype. ^bBy Fisher's exact test for association. CI, confidence interval; OR, odds ratio.

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