Identification of intra-group, inter-individual, and gene-specific variances in mRNA expression profiles in the rheumatoid arthritis synovial membrane

Table 4 KEGG pathways/complexes significantly affected by intra-group inter-individual gene expression variance in osteoarthritis (OA) compared with normal control (that is, higher variances in OA)

	KEGG identification number	Pathway/complex	B (E)	χ²	P value	Affected genes
1	hsa04310	Wnt signaling pathway	7 (4)	3.44	0.21	CSNK2A1, SMAD2, PPP3CB, PRKACA, TBL1X, BTRC, RBX1
1a	hsa04310	Wnt signaling pathway (canonical sub-pathway)	6 (3)	4.56	0.12	CSNK2A1, BTRC, SMAD2, PRKACA, TBL1X, RBX1
2	hsa04210	Apoptosis^a	6 (2)	8.13	0.01	AKT2, IKBKB, PP3CB, PRKACA, RKAR2A, BCL2L
3	hsa03010	Ribosome^a	5 (2)	3.99	0.16	RPL18, RPL35A, RPL38, RPS10, RPL14
3a	hsa03010	Ribosome^a (large subunit)	4 (1)	6.49	0.04	RPL18, RPL35A, RPL38, RPL14
4	hsa04520	Adherens junction^a	5 (2)	5.57	0.07	CSNK2A1, SMAD2, ACP1, TGFBR2, YES1
5	hsa05212	Pancreatic cancer^a	5 (1)	6.22	0.04	AKT2, IKBKB, SMAD2, BCL2L1, TGFBR2
6	hsa04120	Ubiquitin-mediated proteolysis^a	4 (2)	8.12	0.01	ANAPC5, UBE2D2, BTRC, RBX1
7	hsa05050	Dentatorubropallidoluysian atrophy^a	3 (1)	19.79	<0.01	ATN1, RERE, MAGI1

^aSpecifically affected in rheumatoid arthritis. B, absolute frequency; E, expected frequency; KEGG, Kyoto Encyclopedia of Genes and Genomes; Wnt, wingless-type MMTV integration site family.

ISSN: 1478-6362