Identification of intra-group, inter-individual, and gene-specific variances in mRNA expression profiles in the rheumatoid arthritis synovial membrane

Table 5 KEGG pathways/complexes significantly affected by intra-group inter-individual gene expression variance in normal control (NC) compared with osteoarthritis (that is, higher variances in NC)

	KEGG identification number	Pathway/complex	B (E)	χ²	P value	Affected genes
1	hsa04310	Wnt signaling pathway	8 (3)	6.55	0.04	CSNK1A1, DKK2, JUN, MYC, PPP2R1B, PRKACB, WNT5B, FZD1
2	hsa05120	Epithelial cell signaling in Helicobacter pylori infection^a	5 (2)	7.97	0.01	JUN, NFKBIA, ATP6V1C1, ADAM17, ATP6V0D1
3	hsa05211	Renal cell carcinoma^a	5 (2)	7.75	0.01	AKT2, HGF, JUN, TCEB1, VEGFA
4	hsa04620	Toll-like receptor signaling pathway^a	5 (2)	4.43	0.12	AKT2, JUN, NFKBIA, TLR7, STAT1

^aSpecifically affected in rheumatoid arthritis. B, absolute frequency; E, expected frequency; KEGG, Kyoto Encyclopedia of Genes and Genomes; Wnt, wingless-type MMTV integration site family.

ISSN: 1478-6362