Identification of intra-group, inter-individual, and gene-specific variances in mRNA expression profiles in the rheumatoid arthritis synovial membrane

Table 7 KEGG pathways/complexes significantly affected by intra-group inter-individual gene expression variance in osteoarthritis (OA) compared with rheumatoid arthritis (that is, higher variances in OA)

	KEGG identification number	Pathway/complex	B (E)	χ²	P value	Affected genes
1	hsa00190	Oxidative phosphorylation^a	10 (1)	75.6	<0.01	COX5B, NDUFA6, NDUFA8, NDUFB2, NDUFB4, SDHC, NDUFB6, aNDUFC1, NDUFA13, ATP5G3
2	hsa04010	MAPK signaling pathway^a	5 (2)	3.8	0.17	DUSP5, RASGRP3, FAS, MAPK11, TAOK1
2a	hsa04010	MAPK signaling pathway^a (JNK/p38 MAPK sub-pathway)	4 (1)	6.54	0.03	DUSP5, FAS, MAPK11, TAOK1
3	hsa00790	Folate biosynthesis^a	3 (0)	22.03	<0.01	ASCC3, SETX, SMARCA5
4	hsa00500	Starch and sucrose metabolism^a	3 (1)	7.86	0.01	ASCC3, SETX, SMARCA5

^aSpecifically affected in rheumatoid arthritis. B, absolute frequency; E, expected frequency; JNK, c-jun kinase; KEGG, Kyoto Encyclopedia of Genes and Genomes; MAPK, mitogen-activated protein kinase.

ISSN: 1478-6362