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Table 2 Association of STAT4 single nucleotide polymorphisms rs10168266, rs11889341, and rs7574865 with systemic lupus erythematosus

From: Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4region

 

SLE patients (n = 308)

Healthy controls (n = 306)

P value

Odds ratio

95% CI

 

Number

Percentage

Number

Percentage

   

rs10168266

       

Genotype frequency

       

C/C

118

38.3

166

54.2

   

C/T

147

47.7

122

39.9

7.5 × 10-5a

1.91

1.39–2.63a

T/T

43

14.0

18

5.9

   

Allele frequency

       

T

233

37.8

158

25.8

6.3 × 10-6

1.75

1.37–2.23

rs11889341

       

Genotype frequency

       

C/C

99

32.1

153

50.0

   

C/T

161

52.3

126

41.2

6.9 × 10-6a

2.11

1.52–2.92a

T/T

48

15.6

27

8.8

   

Allele frequency

       

T

257

41.7

180

29.4

6.6 × 10-6

1.72

1.36–2.17

rs7574865

       

Genotype frequency

       

G/G

80

26.0

133

43.5

   

G/T

171

55.5

141

46.1

5.3 × 10-6a

2.19

1.56–3.07a

T/T

57

18.5

32

10.5

   

Allele frequency

       

T

285

46.3

205

33.5

4.9 × 10-6

1.71

1.36–2.15

rs10168266/rs11889341/rs7574865

       

Haplotype frequency

       

CCG

 

52.7

 

65.0

1.0 × 10-5b

  

TTT

 

36.8

 

24.3

1.5 × 10-6b

  

CCT

 

4.9

 

5.1

NSb

  

CTT

 

4.6

 

4.1

NSb

  
  1. aP values, odds ratios, and 95% confidence intervals (CIs) were calculated under the dominant model for the minor allele. bP values were calculated by permutation test using Haploview version 4.0 software. Ten million permutations were performed. NS, not significant; SLE, systemic lupus erythematosus; STAT, signal transducers and activators of transcription.
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Arthritis Research & Therapy

ISSN: 1478-6362

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