Unstimulated lupus monocyte-derived dendritic cells, mannose receptor expression, and FITC-dextran uptake. Unstimulated lupus monocyte-derived dendritic cells display decreased mannose receptor (MR) expression, which correlates with FITC-dextran (FD) uptake. (a) Both groups significantly downregulate MR upon lipopolysaccharide/TNF stimulation (*P = 0.007, **P = 0.03, ***P = 0.0002). Results are expressed as the mean ± standard error of the mean. (b) Positive correlation between MR expression and FD uptake. This was observed in unstimulated lupus DCs (*r = 0.64, P < 0.0001) and stimulated lupus DCs (**r = 0.80, P < 0.0001).