Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination

Table 2 Citrullinated peptides detected in experimental autoimmune encephalomyelitis brain tissue

Protein name	Accession number	Total score	Number of peptides	%coverage	cit peptide	p value
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit	[Genbank: 20070412]	205	5	54	KFSPLTANLMNLLAENG(cit)L	0.041
					RLASLSEKPPAIDWAYY(cit)A	0.016
Peroxisomal membrane protein 20	[Genbank: 6746357]	296	4	50	KATDLLLDDSLVSLFGNR(cit)L	0.24
Phosphatidylethanolamine binding protein 1	[Genbank: 84794552]	376	5	52	KLYTLVLTDPDAPS(cit)K	0.088
					KVLTPTQVMN(cit)PSSISWDGLDPGK.L	0.44
					KGNDISSGTVLSDYVGSGPPSGTGLH(cit)Y	7.1e-10
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, ζ	[Genbank: 6756041]	506	14	63	KIETEL(cit)DICNDVLSLLEKF	0.0013
					KTAFDEAIAELDTLSEES YKDSTLIMQLL(cit)D	2.1e-07
Malate dehydrogenase 2, NAD	[Genbank: 31982186]	650	11	61	KVDFPQDQLATLTG(cit)I	0.0025
Glyceraldehyde-3-phosphate dehydrogenase	[Genbank: 55153885]	523	8	41	KLVINGKPTIFQE(cit)D	0.096
Phosphoglycerate kinase 1	[Genbank: 146345481]	143	4	18	KDCVGPEVENACANPAAGTVILLENL(cit)F	0.066
Tubulin, beta 2c	[Genbank: 13542680]	822	13	46	RSGPFGQIF(cit)PDNFVFGQSGAGNNWAKG	0.0056
Atp5b protein	[Genbank: 23272966]	483	15	42	RT(cit)EGNDLYHEMIESGVINLKD	0.00035
					KSLQDIIAILGMDELSEEDKLTVS(cit)A	9.8e-06

ISSN: 1478-6362