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Table 4 Re-synthesised peptides used for determining a major epitope

From: Arthritogenic T cell epitope in glucose-6-phosphate isomerase-induced arthritis

Peptide number

Peptide

Synthetic peptide sequence

18

327–346

H-YI NC F GC E TH A ML P YD Q YLH-OH

 

325–339

H-IWYI NC F GC E THAML-OH

 

334–348

H-ETHA ML P YD Q YLHRF-OH

25

539–558

H-DASTNGL IN F IK Q QREARVQ-OH

 

542–556

  H-TNGL IN F IK Q QREAR-OH

 

544–558

          H-GL IN F IK Q QREARVQ-OH

  1. The 15-mer peptides were synthesised with 90% purity, containing each core sequence of number 18 peptide (GPI327–346) and number 25 peptide (GPI539–558). Amino acid residues constituting the core sequence and those thought to bind the anchors of I-Aq are underlined and shown in bold letters, respectively.
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Arthritis Research & Therapy

ISSN: 1478-6362

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