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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Cartilage oligomeric matrix protein deficiency promotes early onset and the chronic development of collagen-induced arthritis

Figure 1

Cartilage oligomeric matrix protein (COMP)-deficient B10.Q mice show earlier onset and more severe collagen II (CII)-induced arthritis. Arthritis was induced on day 0 by a subcutaneous injection of rat CII emulsified in complete Freund's adjuvant in COMP-deficient mice and B10.Q mice. The mice were boosted on day 30 with an injection of rat CII in incomplete Freund's adjuvant. Arthritis severity was followed for 158 days. Arthritis incidence (a) and mean arthritis score (b) are indicated. The data are representative of three experiments. Asterisks indicate significant differences between COMP-deficient mice (n = 8) and wild-type mice (n = 9) (P < 0.05).

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Arthritis Research & Therapy

ISSN: 1478-6362

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