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Figure 4 | Arthritis Research & Therapy

Figure 4

From: T-614, a novel immunomodulator, attenuates joint inflammation and articular damage in collagen-induced arthritis

Figure 4

Effects of T-614 on cytokine levels in CIA rats. Rats were orally treated with different doses of T-614, nimesulide, MTX and vehicle, beginning on day 12 after the immunization with CIA until day 36. (a) Effects of T-614 on mRNA levels of IFN-γ, IL-4 and IL-17 in lymph node and PBMCs from CIA rats. (b) Effects of T-614 on serum levels of TNF-α, IL-1β, IL-6 and IL-17 in the CIA rats. CIA, collagen-induced arthritis; IFN, interferon; IL, interleukin; LN, lymph node; MTX, methotrexate; PBMC, peripheral blood mononuclear cell.

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Arthritis Research & Therapy

ISSN: 1478-6362

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