Figure 7
Proposed model for how OX40L:OX40 promotes autoimmunity in Sjögren syndrome-like disease of C57BL/6.NOD-Aec1Aec2 mice. Cellular interactions involved in the development of an autoimmune response against the salivary and lacrimal glands leading to loss of acinar tissue are presented. DC, dendritic cell; IL, interleukin; INF-γ, interferon-gamma; MMP, matrix metalloproteinase; NO, nitric oxide, PGE2, prostaglandin E2; TGF-β, transforming growth factor-beta; Treg, regulatory T (cell).