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Figure 1 | Arthritis Research & Therapy

Figure 1

From: All-trans retinoic acid suppresses interleukin-6 expression in interleukin-1-stimulated synovial fibroblasts by inhibition of ERK1/2pathway independently of RAR activation

Figure 1

Effect of interleukin-1-beta (IL-1β) on the expression of retinoic acid receptor (RAR) or retinoid X receptor (RXR) subtypes in synovial fibroblasts. Rat cells were stimulated with 10 ng/mL of IL-1β for 6, 12, or 24 hours for RAR or RXR gene expression and for 24 hours (C for control) for RAR or RXR protein expression. Levels of mRNA of RAR (α, β, γ) (a) or RXR (α, β, γ) (c) quantified by real-time polymerase chain reaction and normalized to ribosomal protein S29 (RP29) are shown. Data are expressed as mean ± standard deviation from three independent experiments. Protein expressions of RAR (α, β, γ) (b) or RXR (α, β) (d) normalized to β-actin are shown. Statistically significant differences from the control are indicated as *P < 0.05.

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Arthritis Research & Therapy

ISSN: 1478-6362

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