No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis

Table 7 Overview of Asp299Gly in TLR4: interesting deviations in allele frequencies

PubMed identifier	Gene	SNP reference	Allele	MA	MAF^a	Odds ratio (P value)	Population	Articular disease
Present study	TLR4	rs4986790	A/G	G	6%/5.0%		100 trios, French	RA
17143969	TLR4	rs4986790	A/G	G	7.5%/2.6%	3.1 (0.037)	CC 101/100, Canadian	AS
16837493	TLR4	rs4986790	A/G	G	15%/14.4%		CC 193/125, Scottish	AS
16567359	TLR4	rs4986790	A/G	G			CC AS138, ReA91/140	AS
15647432	TLR4	rs4986790	A/G	G		1.68	CC 113/170, Dutch	AS
15498795	TLR4	rs4986790	A/G	G	5%		313 trios, UK	JA
15022344	TLR4	rs4986790	A/G	G	5.3%/8.6%		CC 282/314, Dutch	RA
NCBI-SNP	TLR4	rs4986790	A/G	G	?/3.30%		CEU	N/A
NCBI-SNP	TLR4	rs4986790	A/G	G	?/0		HCB	N/A
NCBI-SNP	TLR4	rs4986790	A/G	G	?/0		JPT	N/A
NCBI-SNP	TLR4	rs4986790	A/G	G	?/3.30%		YRI	N/A

^aPresented as cases/controls. NCBI, National Center for Biotechnology Information; CEU, Utah residents with ancestry from northern and western Europe; HCB, Han Chinese in Beijing; JPT, Japanese in Tokyo; YRI, Yoruba in Ibadan, Nigeria; MA, mutation allele; MAF: mutation allele frequency; CC, case control study; RA, rheumatoid arthritis; AS, ankylosing spondylitis; JA, juvenile arthritis; N/A, not applicable.

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