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Table 7 Overview of Asp299Gly in TLR4: interesting deviations in allele frequencies

From: No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis

PubMed identifier Gene SNP reference Allele MA MAFa Odds ratio (P value) Population Articular disease
Present study TLR4 rs4986790 A/G G 6%/5.0%   100 trios, French RA
17143969 TLR4 rs4986790 A/G G 7.5%/2.6% 3.1 (0.037) CC 101/100, Canadian AS
16837493 TLR4 rs4986790 A/G G 15%/14.4%   CC 193/125, Scottish AS
16567359 TLR4 rs4986790 A/G G    CC AS138, ReA91/140 AS
15647432 TLR4 rs4986790 A/G G   1.68 CC 113/170, Dutch AS
15498795 TLR4 rs4986790 A/G G 5%   313 trios, UK JA
15022344 TLR4 rs4986790 A/G G 5.3%/8.6%   CC 282/314, Dutch RA
NCBI-SNP TLR4 rs4986790 A/G G ?/3.30%   CEU N/A
NCBI-SNP TLR4 rs4986790 A/G G ?/0   HCB N/A
NCBI-SNP TLR4 rs4986790 A/G G ?/0   JPT N/A
NCBI-SNP TLR4 rs4986790 A/G G ?/3.30%   YRI N/A
  1. aPresented as cases/controls. NCBI, National Center for Biotechnology Information; CEU, Utah residents with ancestry from northern and western Europe; HCB, Han Chinese in Beijing; JPT, Japanese in Tokyo; YRI, Yoruba in Ibadan, Nigeria; MA, mutation allele; MAF: mutation allele frequency; CC, case control study; RA, rheumatoid arthritis; AS, ankylosing spondylitis; JA, juvenile arthritis; N/A, not applicable.