Dissection of a locus on mouse chromosome 5 reveals arthritis promoting and inhibitory genes

Table 4 CIA phenotypes in C5, C6, C9, C10, and C11 congenic mice

Phenotype^a	B10.RIII^b	C5	B10.RIII^c	C6	C9	C10	C11
Incidence	22/44 (50%)	3/17 (19%)*	32/67 (48%)	6/16 (38%)	1/10 (10%)*	10/15 (67%)	14/19 (74%)*
Onset^d	37 ± 2^e	49 ± 3	34 ± 2	34 ± 4	36	32 ± 1.5	29 ± 1
Severity^f	31 ± 3	24 ± 9	35 ± 3	24 ± 6	24	46 ± 3	48 ± 3*
AUC^g	101 ± 20	13 ± 8*	80 ± 13	40 ± 19	10 ± 10*	137 ± 28	166 ± 27**

^a Values for incidence, onset, mean maximum score and area under the curve (AUC) are the mean phenotype values for the respective congenic mice. The congenic intervals are outlined in Figure 5a. Statistics was calculated with Chi squared test for incidence and Mann-Whitney U test for onset, severity and AUC. * p < 0.05, ** p < 0.01.
^bB10.RIII = littermate controls for mice with the C5 congenic (a/b) fragment.
^cB10.RIII = littermate controls for mice with the C6, C9, C10 and C11 congenic (a/b) fragment.
^dThe day for onset of disease.
^eMean ± standard error of the mean
^fSeverity is the mean of the maximum score of all affected mice in the respective group.
^gAUC is the mean of the total sum of scores for mice in the respective group (day 21 to 69).

ISSN: 1478-6362