Elevated expression of caspase-3 inhibitors, survivin and xIAP correlates with low levels of apoptosis in active rheumatoid synovium

Table 2 Semiquantitative analysis scoring for TRAIL, TRAIL receptors, TUNEL, cleaved caspase-3, survivin and xIAP

	Normal	Active RA	Inactive RA	OA	SpA
TRAIL	1.0 (0 to 3)	3.0 (1 to 4) * † ‡	2.0 (1 to 3)	2.0 (1 to 3)	2.0 (1 to 4) *
TRAIL R1	0 (0 to 2)	3.0 (0 to 4) * † ‡	1.0 (0 to 1)	2.0 (1 to 2) * †	2.0 (0 to 3) * †
TRAIL R2	0 (0 to 3)	2.0 (0 to 4) *	1.0 (0 to 3)	2.0 (0 to 3)	3.0 (1 to 3) *
TRAIL R3	2.0 (0 to 3)	4.0 (1 to 4)	2.0 (0 to 4)	3.0 (1 to 4)	4.0 (3 to 4)
TRAIL R4	1.0 (0 to 2)	3.0 (1 to 4) * ‡	3.0 (1 to 4) *	2.0 (1 to 3)	3.0 (2 to 4) *
TUNEL	0 (0 to 2)	0 (0) †	2.5 (0 to 3)	1.0 (0 to 2)	1.5 (0 to 3)
Caspase-3	0 (0 to 1)	3.0 (1 to 3) * † ‡	1.0 (0 to 1)	1.0 (0 to 1)	2.0 (0 to 2) * †
Survivin	2.0 (1 to 2)	3.0 (2 to 3) * † ‡	2.0 (1 to 2)	2.0 (1 to 2)	2.5 (0 to 3)
xIAP	0.0 (0 to 1)	2.5 (0 to 3)*	1.0 (0 to 1)	2.0 (0 to 3)	0.5 (0.0 to 2.5)

Results are presented as median scores (range).
* p < 0.05 compared with normal synovial tissue
† p < 0.05 compared with inactive rheumatoid arthritis (RA) synovial tissue.
‡ p < 0.05 compared with osteoarthritis (OA) synovial tissue.
SpA = spondyloarthropathies; TRAIL = tumour necrosis factor related apoptosis inducing ligand; TUNEL = terminal deoxynucleotidyl transferase biotin-dUTP nick end labelling; xIAP = x-linked inhibitor of apoptosis protein.

ISSN: 1478-6362