Figure 9

Bovine/human MMP-activity. Supernatants of cartilage monocultures (n = 5, with six replicates each) and co-cultures with synovial fibroblasts (SFB) (n = 5, with six replicates each) with/without stimulation with TNF-α, IL-1β or TNF-α/IL-1β (14 days) were used. Means +/- standard error of the mean are plotted. § p ≤ 0.05 Mann-Whitney U Test compared with non-stimulated control; * p ≤ 0.05 Mann-Whitney U Test compared with stimulation with TNF-α; + p ≤ 0.05 Mann-Whitney U Test compared with cartilage monoculture.