Figure 2From: Insights into endocrine-immunological disturbances in autoimmunity and their impact on treatmentDaily pattern of rheumatoid arthritis symptoms for serum concentrations of IL-6. Proinflammatory hormones (that is, melatonin) start to rise during the early night before the onset of rheumatoid arthritis symptoms and before the endogenous cortisol rise in these patients. Grey shading, trigger time for the IL-6 rise.Back to article page